Article
The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme.
Science (New York, N.Y.) - 13 May 2005
Tews Ivo, Findeisen Felix, Sinning Irmgard, Schultz Anita, Schultz Joachim E, Linder Jürgen U
Abstract excerpt
Class III adenylyl cyclases contain catalytic and regulatory domains, yet structural insight into their interactions is missing. We show that the mycobacterial adenylyl cyclase Rv1264 is rendered a pH sensor by its N-terminal domain. In the structure of the inhibited state, catalytic and regulatory domains share a large interface involving catalytic residues. In the structure of the active state, the two...
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