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Article

Identification and Characterization of a Unique Adenosine Kinase from <i>Mycobacterium tuberculosis</i>

2 Nov 2003

Abstract excerpt

Adenosine kinase (AK) is a purine salvage enzyme that catalyzes the phosphorylation of adenosine to AMP. In Mycobacterium tuberculosis, AK can also catalyze the phosphorylation of the adenosine analog 2-methyladenosine (methyl-Ado), the first step in the metabolism of this compound to an active form. Purification of AK from M. tuberculosis yielded a 35-kDa protein that existed as a dimer in its native form....

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PMID: 14594827
DOI: 10.1128/jb.185.22.6548-6555.2003

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