Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264.

International journal of medical microbiology : IJMM - 1 Dec 2006

Dittrich Dorothea, Keller Christine, Ehlers Stefan, Schultz Joachim E, Sander Peter

Abstract excerpt

Mycobacterium tuberculosis open reading frame Rv1264 encodes an adenylate cyclase that exhibits its highest enzymatic activity at an acidic pH of 6.0. This is the pH M. tuberculosis encounters in the phagosome. Consequently Rv1264 has been suggested to sense the phagosomal milieu resulting in adaption of M. tuberculosis to its intracellular niche. A targeted knock-out mutant deficient in Rv1264, however, exhibits...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylyl Cyclases
Share to Hydrogen-Ion Concentration

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mutation

Share to Mycobacterium tuberculosis

Share to Open Reading Frames

Source

Identifiers

PMID: 17005450
DOI: 10.1016/j.ijmm.2006.07.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264.PMID 17005450Read ↗

The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme.Semantic proximity Read ↗

Clinically relevant mutations in the PhoR sensor kinase of host-adapted Mycobacterium abscessus isolates impact response to acidic pH and virulence.Semantic proximity Read ↗

Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.Semantic proximity Read ↗

A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.Semantic proximity Read ↗

Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection.Semantic proximity Read ↗

Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener.Semantic proximity Read ↗

A structural basis for the role of nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis.Semantic proximity Read ↗

Purification, crystallization and preliminary X-ray diffraction analysis of the catalytic domain of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis.Semantic proximity Read ↗

A genetically encoded biosensor reveals heterogenous cAMP dynamics coordinating growth and resuscitation in Mycobacterium tuberculosisSemantic proximity Read ↗

The role of transcriptional regulation in maintaining the availability of mycobacterial adenylate cyclasesSemantic proximity Read ↗

Characterization of differential pore-forming activities of ESAT-6 proteins from Mycobacterium tuberculosis and Mycobacterium smegmatis.Semantic proximity Read ↗

Bordetella Adenylate Cyclase-Hemolysin ToxinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.