Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease.

doi:10.1016/j.parkreldis.2015.02.009

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Article

Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease.

Parkinsonism & related disorders - 1 May 2015

Muellner Julia, Gharrad Iman, Habert Marie-Odile, Kas Aurélie, Martini Jean-Baptiste, Cormier-Dequaire Florence, Tahiri Khadija, Vidailhet Marie, Meier Niklaus, Brice Alexis, Schuepbach Michael, Mallet Alain, Hartmann Andreas, Corvol Jean-Christophe

Abstract excerpt

BACKGROUND: Catecholamine-O-methyl-tranferase (COMT) initiates dopamine degradation. Its activity is mainly determined by a single nucleotide polymorphism in the COMT gene (Val158Met, rs4680) separating high (Val/Val, COMT(HH)), intermediate (Val/Met, COMT(HL)) and low metabolizers (Met/Met, COMT...

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PMID: 25753458
DOI: 10.1016/j.parkreldis.2015.02.009

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COMT
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25753458-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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