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Article

Role of the COMT gene Val158Met polymorphism in mental disorders: a review.

European psychiatry : the journal of the Association of European Psychiatrists - 1 Jul 2007

Hosák Ladislav

Abstract excerpt

The Val158Met polymorphism of the COMT gene is functional, easily detectable, and significantly related to metabolism of catecholamines, which underlie pathogenesis of a significant number of mental disorders. Evidence for the role of this polymorphism in schizophrenia, substance dependence, bipolar disorder, obsessive-compulsive disorder, anorexia nervosa and attention deficit hyperactivity disorder is summed up...

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Topics

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Share to Catechol O-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17419009
DOI: 10.1016/j.eurpsy.2007.02.002

Genes

COMT

Provenance

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Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Role of the COMT gene Val158Met polymorphism in mental disorders: a review.PMID 17419009Read ↗

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The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

Association of COMT Val158Met Polymorphism with Psychopathological Symptoms in Patients with Eating Disorders.Semantic proximity Read ↗

Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender.Semantic proximity Read ↗

Catechol-O-methyl transferase and schizophrenia.Semantic proximity Read ↗

The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Semantic proximity Read ↗

[Genetic polymorphism of COMT in mental disorders].Semantic proximity Read ↗

Val158Met polymorphism in the COMT gene is associated with hypersomnia and mental health-related quality of life in a Colombian sample.Semantic proximity Read ↗

A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype.Semantic proximity Read ↗

Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report.Semantic proximity Read ↗

Association of Val158Met polymorphism in COMT gene with attention-deficit hyperactive disorder: An updated meta-analysis.Semantic proximity Read ↗

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