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Article

Impact of the COMT Val(108/158)Met polymorphism on the mu-opioid receptor system in the human brain: mu-opioid receptor, met-enkephalin and beta-endorphin expression.

Neuroscience letters - 11 Jan 2012

Kowarik Markus C, Einhäuser Julia, Jochim Burkard, Büttner Andreas, Tölle Thomas R, Riemenschneider Matthias, Platzer Stefan, Berthele Achim

Abstract excerpt

The Val(108/158)Met polymorphism of the catechol-O-methyltransferase gene (COMT) is known to interact with the function of various neuroreceptor systems in the brain. We have recently shown by post-mortem receptor autoradiography that the number of mu-opioid (MOP) receptor binding sites depends o...

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Source

Identifiers

PMID: 22101356
DOI: 10.1016/j.neulet.2011.11.008

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22101356-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Impact of the COMT Val(108/158)Met polymorphism on the mu-opioid receptor system in the human brain: mu-opioid receptor, met-enkephalin and beta-endorphin expression.PMID 22101356Read ↗

COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression.Semantic proximity Read ↗

Role of the COMT gene Val158Met polymorphism in mental disorders: a review.Semantic proximity Read ↗

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Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report.Semantic proximity Read ↗

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Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism.Semantic proximity Read ↗

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