Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltransferase genotype modulates opioid release in decision circuitry.

Clinical and translational science - 1 Oct 2013

Mitchell Jennifer M, O'Neil James P, Jagust William J, Fields Howard L

Abstract excerpt

Impulsivity, a risk factor for substance abuse disorders, is modulated by the Val158 variant of the catechol-O-methyltransferase (COMT) gene. Rodent studies have shown that opioids enhance impulsivity. Furthermore, alcohol consumption leads to endogenous opioid release in the cortex and nucleus accumbens (NAc), and this opioid release is correlated with greater positive hedonic effect. Using the selective mu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Amino Acid Substitution
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Decision Making

Share to COMT gene

Share to Genotype

Share to Impulsive Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 24127930
DOI: 10.1111/cts.12075
PMCID: PMC5350883

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase genotype modulates opioid release in decision circuitry.PMID 24127930Read ↗

Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.Semantic proximity Read ↗

The catechol-O-methyl transferase Val158Met polymorphism and susceptibility to cannabis dependence.Semantic proximity Read ↗

COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression.Semantic proximity Read ↗

Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism.Semantic proximity Read ↗

Opioid and Dopamine Genes Interact to Predict Naltrexone Response in a Randomized Alcohol Use Disorder Clinical Trial.Semantic proximity Read ↗

Catechol-O-methyltransferase genotype and dopamine regulation in the human brain.Semantic proximity Read ↗

Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait.Semantic proximity Read ↗

COMT Val158Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase InhibitionSemantic proximity Read ↗

Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity.Semantic proximity Read ↗

Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues.Semantic proximity Read ↗

Variation in dopamine genes influences responsivity of the human reward system.Semantic proximity Read ↗

Effect of catechol-O-methyltransferase val158met genotype on attentional control.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.