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Article

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.

The Journal of cell biology - 18 Jul 2005

Mills Ian G, Gaughan Luke, Robson Craig, Ross Theodora, McCracken Stuart, Kelly John, Neal David E

Abstract excerpt

Internalization of activated receptors regulates signaling, and endocytic adaptor proteins are well-characterized in clathrin-mediated uptake. One of these adaptor proteins, huntingtin interacting protein 1 (HIP1), induces cellular transformation and is overexpressed in some prostate cancers. We have discovered that HIP1 associates with the androgen receptor through a central coiled coil domain and is recruited...

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Source

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Identifiers

PMID: 16027218
DOI: 10.1083/jcb.200503106
PMCID: PMC2171420

Genes

HIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.PMID 16027218Read ↗

HIP1: trafficking roles and regulation of tumorigenesis.Semantic proximity Read ↗

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.Semantic proximity Read ↗

It's HIP to be a hub: new trends for old-fashioned proteins.Semantic proximity Read ↗

Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.Semantic proximity Read ↗

Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts.Semantic proximity Read ↗

Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.Semantic proximity Read ↗

Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1.Semantic proximity Read ↗

CHD1, a multifaceted epigenetic remodeler in prostate cancerSemantic proximity Read ↗

ABI1 regulates transcriptional activity of Androgen Receptor by novel DNA and AR binding mechanismSemantic proximity Read ↗

CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer.Semantic proximity Read ↗

Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.Semantic proximity Read ↗

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.Semantic proximity Read ↗

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