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Article

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.

The Journal of biological chemistry - 19 Oct 2001

Metzler M, Legendre-Guillemin V, Gan L, Chopra V, Kwok A, McPherson P S, Hayden M R

Abstract excerpt

Polyglutamine expansion in huntingtin is the underlying mutation leading to neurodegeneration in Huntington disease. This mutation influences the interaction of huntingtin with different proteins, including huntingtin-interacting protein 1 (HIP1), in which affinity to bind to mutant huntingtin is profoundly reduced. Here we demonstrate that HIP1 colocalizes with markers of clathrin-mediated endocytosis in...

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Identifiers

PMID: 11517213
DOI: 10.1074/jbc.C100401200

Genes

HIP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.PMID 11517213Read ↗

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Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.Semantic proximity Read ↗

Structural definition of the F-actin-binding THATCH domain from HIP1R.Semantic proximity Read ↗

Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.Semantic proximity Read ↗

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Recent Advances in the Study of Huntingtin Interacting ProteinsSemantic proximity Read ↗

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