Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer.

Cancer research - 1 May 2013

Burkhardt Lia, Fuchs Sarah, Krohn Antje, Masser Sawinee, Mader Malte, Kluth Martina, Bachmann Frederik, Huland Hartwig, Steuber Thomas, Graefen Markus, Schlomm Thorsten, Minner Sarah, Sauter Guido, Sirma Hüseyin, Simon Ronald

Abstract excerpt

Deletions involving the chromosomal band 5q21 are among the most frequent alterations in prostate cancer. Using single-nucleotide polymorphism (SNP) arrays, we mapped a 1.3 megabase minimally deleted region including only the repulsive guidance molecule B (RGMB) and chromodomain helicase DNA-binding protein 1 (CHD1) genes. Functional analyses showed that CHD1 is an essential tumor suppressor. FISH analysis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 5
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Genes, Tumor Suppressor

Share to Prostate-Specific Antigen

Share to Receptors, Androgen

Share to Transcriptional Regulator ERG

Share to Translocation, Genetic

Source

Identifiers

PMID: 23492366
DOI: 10.1158/0008-5472.CAN-12-1342

Genes

CHD1
ERG
FOXO1
RGMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer.PMID 23492366Read ↗

CHD1, a multifaceted epigenetic remodeler in prostate cancerSemantic proximity Read ↗

Identification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer.Semantic proximity Read ↗

CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair.Semantic proximity Read ↗

The genomic complexity of primary human prostate cancerSemantic proximity Read ↗

Distinct genomic aberrations associated with ERG rearranged prostate cancerSemantic proximity Read ↗

CHD6 promotes broad nucleosome eviction for transcriptional activation in prostate cancer cellsSemantic proximity Read ↗

MDC1 functionally identified as an androgen receptor co-activator participates in suppression of prostate cancerSemantic proximity Read ↗

Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiencySemantic proximity Read ↗

Chromosomal deletions and tumor suppressor genes in prostate cancer.Semantic proximity Read ↗

Chromosomal aberrations in prostate cancerSemantic proximity Read ↗

Frequent Disruption of Chromodomain Helicase DNA-Binding Protein 8 (CHD8) and Functionally Associated Chromatin Regulators in Prostate CancerSemantic proximity Read ↗

The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.