Article
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.
The EMBO journal - 1 Jul 2003
Metzler Martina, Li Bo, Gan Lu, Georgiou John, Gutekunst Claire-Anne, Wang Yushan, Torre Enrique, Devon Rebecca S, Oh Rosemary, Legendre-Guillemin Valerie, Rich Mark, Alvarez Christine, Gertsenstein Marina, McPherson Peter S, Nagy Andras, Wang Yu Tian, Roder John C, Raymond Lynn A, Hayden Michael R
Abstract excerpt
Huntingtin interacting protein 1 (HIP1) is a recently identified component of clathrin-coated vesicles that plays a role in clathrin-mediated endocytosis. To explore the normal function of HIP1 in vivo, we created mice with targeted mutation in the HIP1 gene (HIP1(-/-)). HIP1(-/-) mice develop a neurological phenotype by 3 months of age manifest with a failure to thrive, tremor and a gait ataxia secondary to a...
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