Article
Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.
Human molecular genetics - 1 Jun 2007
Bradley Sarah V, Hyun Teresa S, Oravecz-Wilson Katherine I, Li Lina, Waldorff Erik I, Ermilov Alexander N, Goldstein Steven A, Zhang Claire X, Drubin David G, Varela Kate, Parlow Al, Dlugosz Andrzej A, Ross Theodora S
Abstract excerpt
The members of the huntingtin-interacting protein-1 (HIP1) family, HIP1 and HIP1-related (HIP1r), are multi-domain proteins that interact with inositol lipids, clathrin and actin. HIP1 is over-expressed in a variety of cancers and both HIP1 and HIP1r prolong the half-life of multiple growth factor receptors. To better understand the physiological importance of the HIP1 family in vivo, we have analyzed a large...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- DNA-Binding Proteins
- Genes, Lethal
- Humans
- Introns
- Kyphosis
- Lordosis
- Mice
- Mice, Knockout
- Microfilament Proteins
- Phenotype
- Weight Loss