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Article

It's HIP to be a hub: new trends for old-fashioned proteins.

The Journal of cell biology - 18 Jul 2005

Vecchi Manuela, Di Fiore Pier Paolo

Abstract excerpt

Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a...

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Identifiers

PMID: 16009727
DOI: 10.1083/jcb.200506039
PMCID: PMC2171400

Genes

HIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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It's HIP to be a hub: new trends for old-fashioned proteins.PMID 16009727Read ↗

HIP1: trafficking roles and regulation of tumorigenesis.Semantic proximity Read ↗

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.Semantic proximity Read ↗

Recent Advances in the Study of Huntingtin Interacting ProteinsSemantic proximity Read ↗

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.Semantic proximity Read ↗

Integration of stress signals by homeodomain interacting protein kinasesSemantic proximity Read ↗

[Elaboration of newly discovered functions of budding yeast homolog Sla2p of protein HIP1 (Huntington-interacting protein 1) that binds huntingtin, a Huntington-causing protein].Semantic proximity Read ↗

Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.Semantic proximity Read ↗

Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.Semantic proximity Read ↗

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.Semantic proximity Read ↗

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.Semantic proximity Read ↗

At the nucleus of the problem: nuclear proteins and disease.Semantic proximity Read ↗

Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s DiseaseSemantic proximity Read ↗

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