Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

It's HIP to be a hub: new trends for old-fashioned proteins.

The Journal of cell biology - 18 Jul 2005

Vecchi Manuela, Di Fiore Pier Paolo

Abstract excerpt

Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a...

Topics

Cell Nucleus
DNA-Binding Proteins
Endocytosis
Humans
Mutation
Nuclear Localization Signals
Protein Transport
Receptors, Androgen
Response Elements
Transcription, Genetic
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 16009727
DOI: 10.1083/jcb.200506039
PMCID: PMC2171400

Genes

HIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

It's HIP to be a hub: new trends for old-fashioned proteins.PMID 16009727Read ↗

HIP1: trafficking roles and regulation of tumorigenesis.Semantic proximity Read ↗

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.Semantic proximity Read ↗

Recent Advances in the Study of Huntingtin Interacting ProteinsSemantic proximity Read ↗

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.Semantic proximity Read ↗

Integration of stress signals by homeodomain interacting protein kinasesSemantic proximity Read ↗

[Elaboration of newly discovered functions of budding yeast homolog Sla2p of protein HIP1 (Huntington-interacting protein 1) that binds huntingtin, a Huntington-causing protein].Semantic proximity Read ↗

Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.Semantic proximity Read ↗

Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.Semantic proximity Read ↗

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.Semantic proximity Read ↗

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.Semantic proximity Read ↗

At the nucleus of the problem: nuclear proteins and disease.Semantic proximity Read ↗

Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.