Article
Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.
Molecular and cellular biology - 1 Sept 2013
Ames Heather M, Wang Anmin A, Coughran Alanna, Evaul Kristen, Huang Sha, Graves Chiron W, Soyombo Abigail A, Ross Theodora S
Abstract excerpt
Huntingtin-interacting protein 1 (HIP1) binds inositol lipids, clathrin, actin, and receptor tyrosine kinases (RTKs). HIP1 is elevated in many tumors, and its expression is prognostic in prostate cancer. HIP1 overexpression increases levels of the RTK epidermal growth factor receptor (EGFR) and transforms fibroblasts. Here we report that HIP1 is tyrosine phosphorylated in the presence of EGFR and platelet-derived...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Motifs
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- COS Cells
- Chlorocebus aethiops
- DNA-Binding Proteins
- ErbB Receptors
- HEK293 Cells
- HeLa Cells
- Humans
- Mice