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Article

Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.

The Journal of biological chemistry - 28 Jul 2006

Cestèle Sandrine, Yarov-Yarovoy Vladimir, Qu Yusheng, Sampieri François, Scheuer Todd, Catterall William A

Abstract excerpt

Voltage sensing by voltage-gated sodium channels determines the electrical excitability of cells, but the molecular mechanism is unknown. beta-Scorpion toxins bind specifically to neurotoxin receptor site 4 and induce a negative shift in the voltage dependence of activation through a voltage sensor-trapping mechanism. Kinetic analysis showed that beta-scorpion toxin binds to the resting state, and subsequently...

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Identifiers

PMID: 16679310
DOI: 10.1074/jbc.M603814200
PMCID: PMC1551974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.PMID 16679310Read ↗

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