Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.

doi:10.1016/s0896-6273(00)80606-6

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Article

Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.

Neuron - 1 Oct 1998

Cestèle S, Qu Y, Rogers J C, Rochat H, Scheuer T, Catterall W A

Abstract excerpt

Polypeptide neurotoxins alter ion channel gating by binding to extracellular receptor sites, even though the voltage sensors are in their S4 transmembrane segments. By analysis of sodium channel chimeras, a beta-scorpion toxin is shown here to negatively shift voltage dependence of activation and...

Topics

Amino Acid Sequence
Brain
Cell Line
Chimera
Ion Channel Gating
Mutation
Myocardium
Scorpion Venoms
Sodium Channels

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