Article
Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.
Neuron - 1 Oct 1998
Cestèle S, Qu Y, Rogers J C, Rochat H, Scheuer T, Catterall W A
Abstract excerpt
Polypeptide neurotoxins alter ion channel gating by binding to extracellular receptor sites, even though the voltage sensors are in their S4 transmembrane segments. By analysis of sodium channel chimeras, a beta-scorpion toxin is shown here to negatively shift voltage dependence of activation and enhance closed state inactivation by binding to a receptor site that requires glycine 845 (Gly-845) in the S3-S4 loop...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.