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Article

Partial agonist and antagonist activities of a mutant scorpion beta-toxin on sodium channels.

The Journal of biological chemistry - 1 Oct 2010

Karbat Izhar, Ilan Nitza, Zhang Joel Z, Cohen Lior, Kahn Roy, Benveniste Morris, Scheuer Todd, Catterall William A, Gordon Dalia, Gurevitz Michael

Abstract excerpt

Scorpion β-toxin 4 from Centruroides suffusus suffusus (Css4) enhances the activation of voltage-gated sodium channels through a voltage sensor trapping mechanism by binding the activated state of the voltage sensor in domain II and stabilizing it in its activated conformation. Here we describe the antagonist and partial agonist properties of a mutant derivative of this toxin. Substitution of seven different...

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Identifiers

PMID: 20682774
DOI: 10.1074/jbc.M110.150888
PMCID: PMC2945547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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