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Suppression of beta-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats.

Oncology reports - 1 Aug 2005

Hara Akira, Sakata Keiko, Yamada Yasuhiro, Kuno Toshiya, Kitaori Nami, Oyama Takeru, Hirose Yoshinobu, Murakami Akira, Tanaka Takuji, Mori Hideki

Abstract excerpt

Alteration of beta-catenin expression in hepatocellular carcinomas (HCCs) may play an important role in tumor progression by stimulating cell proliferation. We have previously reported that auraptene (AUR), an antioxidant agent isolated from citrus fruit, effectively inhibits chemically induced hepatocarcinogenesis in rats. In this study, we investigated the molecular mechanism of the inhibitory effects of...

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PMID: 16012713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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