Article
Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma.
Cancer prevention research (Philadelphia, Pa.) - 1 Jun 2020
Sojoodi Mozhdeh, Wei Lan, Erstad Derek J, Yamada Suguru, Fujii Tsutomu, Hirschfield Hadassa, Kim Rosa S, Lauwers Gregory Y, Lanuti Michael, Hoshida Yujin, Tanabe Kenneth K, Fuchs Bryan C
Abstract excerpt
Hepatocellular carcinoma (HCC) is a highly morbid condition with lack of effective treatment options. HCC arises from chronically inflamed and damaged liver tissue; therefore, chemoprevention may be a useful strategy to reduce HCC incidence. Several reports suggest that epigallocatechin gallate (EGCG), extracted from green tea, can suppress liver inflammation and fibrosis in animal models, but its role in HCC...
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