Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aristolochic acid activates ras genes in rat tumors at deoxyadenosine residues.

Cancer research - 1 Sept 1990

Schmeiser H H, Janssen J W, Lyons J, Scherf H R, Pfau W, Buchmann A, Bartram C R, Wiessler M

Abstract excerpt

Aristolochic acid I (AAI), a nitrophenanthrene derivative, is the major component of the carcinogenic plant extract aristolochic acid, which has been used as a medicine since antiquity. Long term oral administration of AAI to male Wistar rats induces multiple tumors, mainly in the forestomach, ear duct, and small intestine. The presence of activated transforming genes was investigated in various tumors of 18 AAI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Codon
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, ras

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 2201437

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aristolochic acid activates ras genes in rat tumors at deoxyadenosine residues.PMID 2201437Read ↗

Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice.Semantic proximity Read ↗

Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.Semantic proximity Read ↗

Aristolochic acid as a probable human cancer hazard in herbal remedies: a reviewSemantic proximity Read ↗

The Mutational Features of Aristolochic Acid-Induced Mouse and Human Liver Cancers.Semantic proximity Read ↗

DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver.Semantic proximity Read ↗

ras gene activation in rat tumors induced by benzidine congeners and derived dyes.Semantic proximity Read ↗

The mutational features of aristolochic acid-induced mouse and human liver cancersSemantic proximity Read ↗

Activating mutation of the Ha-ras gene in chemically induced tumors of the hamster cheek pouch.Semantic proximity Read ↗

Activation of H-ras oncogenes in preneoplastic mouse mammary tissues.Semantic proximity Read ↗

Mutational activation of the cellular Harvey ras oncogene in rat esophageal papillomas induced by methylbenzylnitrosamine.Semantic proximity Read ↗

Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of miceSemantic proximity Read ↗

Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.