Aristolochic acid activates ras genes in rat tumors at deoxyadenosine residues.

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Article

Aristolochic acid activates ras genes in rat tumors at deoxyadenosine residues.

Cancer research - 1 Sept 1990

Schmeiser H H, Janssen J W, Lyons J, Scherf H R, Pfau W, Buchmann A, Bartram C R, Wiessler M

Abstract excerpt

Aristolochic acid I (AAI), a nitrophenanthrene derivative, is the major component of the carcinogenic plant extract aristolochic acid, which has been used as a medicine since antiquity. Long term oral administration of AAI to male Wistar rats induces multiple tumors, mainly in the forestomach, ea...

Topics

Animals
Aristolochic Acids
Base Sequence
Carcinogens
Codon
DNA, Neoplasm
Gene Expression Regulation, Neoplastic
Genes, ras
Male
Molecular Sequence Data
Mutation
Neoplasms, Experimental
Oligonucleotide Probes
Phenanthrenes
Polymerase Chain Reaction
Rats
Rats, Inbred Strains

Source

Open in PubMed

Identifiers

PMID: 2201437

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2201437-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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