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Article

Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2016

Kuwata Kazunori, Inoue Kaoru, Ichimura Ryohei, Takahashi Miwa, Kodama Yukio, Shibutani Makoto, Yoshida Midori

Abstract excerpt

Acifluorfen (ACI), a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Porphyria is a risk factor for liver tumors in humans; however, the specific mechanisms through which ACI induces hepatocarcinogenesis in rodents are unclear. Here, we investigated the mode of action of ACI-induced hepatocarcinogenesis,...

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PMID: 26928356
DOI: 10.1093/toxsci/kfw040

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