Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

β-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice.

Toxicologic pathology - 1 Jun 2017

Kuwata Kazunori, Inoue Kaoru, Ichimura Ryohei, Takahashi Miwa, Kodama Yukio, Shibutani Makoto, Yoshida Midori

Abstract excerpt

We previously reported the contribution of constitutive androstane receptor (CAR) in cytotoxicity-related hepatocarcinogenesis induced by oxadiazon (OX) or acifluorfen (ACI), two pesticides categorized as protoporphyrinogen oxidase (PROTOX) inhibitors. The molecular characteristics of preneoplastic and neoplastic lesions induced by OX and ACI were immunohistochemically compared to those by phenobarbital (PB), a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens
Share to Constitutive Androstane Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamate-Ammonia Ligase

Share to Liver Neoplasms, Experimental

Share to Oxadiazoles

Share to Phenobarbital

Share to Protoporphyrinogen Oxidase

Share to Receptors, Cytoplasmic and Nuclear

Source

Identifiers

PMID: 28580885
DOI: 10.1177/0192623317708898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

β-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice.PMID 28580885Read ↗

Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.Semantic proximity Read ↗

Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital.Semantic proximity Read ↗

Beta-catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam.Semantic proximity Read ↗

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.Semantic proximity Read ↗

Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice.Semantic proximity Read ↗

A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors.Semantic proximity Read ↗

High Frequency of β-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist.Semantic proximity Read ↗

Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.Semantic proximity Read ↗

Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade.Semantic proximity Read ↗

Critical cholangiocarcinogenesis control by cryptochrome clock genes.Semantic proximity Read ↗

Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice.Semantic proximity Read ↗

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.