Article
Molecular analysis of the EGFR gene in astrocytic gliomas: mRNA expression, quantitative-PCR analysis of non-homogeneous gene amplification and DNA sequence alterations.
Neuropathology and applied neurobiology - 1 Aug 2005
Arjona D, Bello M J, Alonso M E, Aminoso C, Isla A, De Campos J M, Sarasa J L, Gutierrez M, Villalobo A, Rey J A
Abstract excerpt
The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with tyrosine kinase activity. This report investigates the presence of mutations, amplification and/or over-expression of the EGFR gene in 86 glial tumours including 44 glioblastomas, 21 anaplastic astrocytomas, and 21 WHO grade II astrocytomas, using polymerase chain reaction/single-strand conformation polymorphism, semiquantitative...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.