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Article

Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas.

Anticancer research - 1 Jan 2000

Viana-Pereira Marta, Lopes José Manuel, Little Suzie, Milanezi Fernanda, Basto Diana, Pardal Fernando, Jones Chris, Reis Rui Manuel

Abstract excerpt

BACKGROUND: Patients with malignant gliomas do not respond to any current therapy. Epidermal growth factor receptor (EGFR) controls several oncogenic processes, being frequently up-regulated in gliomas due to overexpression, gene amplification and gene mutation. EGFR inhibitors are being tried in...

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Source

Identifiers

PMID: 18507036

Genes

EGFR
CISH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18507036-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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