Article
Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma.
International journal of cancer - 2 Jan 1994
Schlegel J, Merdes A, Stumm G, Albert F K, Forsting M, Hynes N, Kiessling M
Abstract excerpt
The objective of our study was to determine the frequency of EGF-receptor-gene rearrangement in relation to tumour-growth behaviour in an unselected group of glioma patients. We investigated 73 glial tumours with different grades of malignancy (17 low-grade gliomas, 14 anaplastic variants, and 42...
Topics
- Adolescent
- Adult
- Blotting, Southern
- Blotting, Western
- Brain Neoplasms
- Child
- ErbB Receptors
- Female
- Gene Amplification
- Gene Rearrangement
- Glioblastoma
- Glioma
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction