A case of glioblastoma harboring non-amplified epidermal growth factor receptor variant III: Critical molecular detection using RNA-based panel analysis.

doi:10.1016/j.prp.2023.154712

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Article

A case of glioblastoma harboring non-amplified epidermal growth factor receptor variant III: Critical molecular detection using RNA-based panel analysis.

Pathology, research and practice - 1 Aug 2023

Kirishima Mari, Akahane Toshiaki, Takajo Tomoko, Higa Nayuta, Yonezawa Hajime, Uchida Hiroyuki, Kamimura Kiyohisa, Hanaya Ryosuke, Yoshimoto Koji, Higashi Michiyo, Yoshiura Takashi, Tanimoto Akihide

Abstract excerpt

Amplification of the epidermal growth factor receptor gene (EGFR) and its variants are the most commonly detected pathogenic gene alterations in glioblastoma. Herein, we report a case of molecularly defined glioblastoma harboring an EGFR variant III (EGFRvIII) without EGFR amplification. The initial histological diagnosis was isocitrate dehydrogenase (IDH)-wildtype low-grade glioma, due to an absence of...

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PMID: 37499520
DOI: 10.1016/j.prp.2023.154712

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