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Article

EGFR gene amplification ‐ rearrangement in human glioblastomas

17 Jul 1995

Abstract excerpt

Immunostaining using an affinity-purified rabbit polyclonal antibody against the extracellular domain of the epidermal-growth-factor receptor (EGFR) showed over-expression occurring in a fraction of tumor cells in 17 out of 18 human glioblastomas and in a majority of cells in 7 of the 18. Southern-blotting technique using a full-length EGFR cDNA probe showed a variable degree of amplification in 10 of the 17...

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PMID: 7622287
DOI: 10.1002/ijc.2910620206

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