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Article

Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2005

Liu Lu, Bäcklund L Magnus, Nilsson Bo R, Grandér Dan, Ichimura Koichi, Goike Helena M, Collins V Peter

Abstract excerpt

The aim of this study was to evaluate the clinical value of assessing epidermal growth factor receptor (EGFR) amplification and the common 5' rearrangement of EGFR resulting in the EGFRvIII transcript in astrocytic gliomas. Data from 221 tumours were correlated with patient survival. The majority of previous studies evaluated amplification alone and provided contradictory results. Amplification was analysed by a...

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Source

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Identifiers

PMID: 16133418
DOI: 10.1007/s00109-005-0700-2
PMCID: PMC2815848

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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