Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction.

European journal of pharmacology - 1 Aug 2011

Choi Sun-Hye, Shin Tae-Joon, Hwang Sung-Hee, Lee Byung-Hwan, Kang Jiyeon, Kim Hyeon-Joong, Jo Su-Hyun, Choe Han, Nah Seung-Yeol

Abstract excerpt

The human ether-a-go-go-related gene (hERG) cardiac K(+) channels are one of the representative pharmacological targets for development of drugs against cardiovascular diseases such as arrhythmia. Panax ginseng has been known to have cardio-protective effects. However, little is known about the molecular mechanisms of how ginsenosides, the active ingredients in Panax ginseng, interact with hERG K(+) channel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electric Conductivity

Share to ERG1 Potassium Channel

Share to Ether-A-Go-Go Potassium Channels

Share to Mutagenesis, Site-Directed

Share to Protein Binding

Share to Serine

Source

Identifiers

PMID: 21586280
DOI: 10.1016/j.ejphar.2011.05.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction.PMID 21586280Read ↗

Ginsenoside Rg3 enhances large conductance Ca2+-activated potassium channel currents: a role of Tyr360 residue.Semantic proximity Read ↗

Ginsenoside Rg3 activates human KCNQ1 K+ channel currents through interacting with the K318 and V319 residues: a role of KCNE1 subunit.Semantic proximity Read ↗

Mutations Leu427, Asn428, and Leu431 residues within transmembrane domain-I-segment 6 attenuate ginsenoside-mediated L-type Ca(2+) channel current inhibitions.Semantic proximity Read ↗

Clenbuterol Attenuates hERG Channel by Promoting the Mature Channel Degradation.Semantic proximity Read ↗

I(Kr): the hERG channel.Semantic proximity Read ↗

[HERG K+ channel, the target of anti-arrhythmias drugs].Semantic proximity Read ↗

The evolutionarily conserved residue A653 plays a key role in HERG channel closing.Semantic proximity Read ↗

Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels.Semantic proximity Read ↗

A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel.Semantic proximity Read ↗

Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin.Semantic proximity Read ↗

A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.Semantic proximity Read ↗

HERG, a human inward rectifier in the voltage-gated potassium channel family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.