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Article

Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2005

Bagavant Harini, Tung Kenneth S K

Abstract excerpt

The development of organ-specific autoimmune diseases in mice thymectomized on day 3 of life (d3tx mice) can be prevented by transferring CD4(+)CD25(+) T cells from syngeneic, normal adult mice. Using a d3tx model, we asked whether CD4(+)CD25(+) T cell deficiency contributes to glomerulonephritis (GN) in lupus-prone mice. New Zealand Mixed 2328 (NZM2328) mice spontaneously develop autoantibodies to dsDNA and...

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Share to Antibodies, Antinuclear
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glomerulonephritis, Membranoproliferative

Share to Kidney Glomerulus

Share to Lupus Nephritis

Share to Receptors, Interleukin-2

Share to T-Lymphocytes, Regulatory

Share to Thyroiditis, Autoimmune

Source

Identifiers

PMID: 16002693
DOI: 10.4049/jimmunol.175.2.944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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