Article
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. Characterization of thyroiditis-inducing T cell lines and clones derived from thyroid lesions.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1993
Sugihara S, Fujiwara H, Shearer G M
Abstract excerpt
We have previously shown that autoimmune thyroiditis spontaneously develops in T cell-depleted (C57BL/6xC3H/He)F1 mice after adoptive transfer of syngeneic lymphoid cells that have been depleted of CD5bright T lymphocytes. This mouse model was considered to be an instructive model for Hashimoto's...
Topics
- Animals
- Antigens, CD
- CD5 Antigens
- Cell Line
- Clone Cells
- Epitopes
- Female
- H-2 Antigens
- Lymphocyte Activation
- Mice
- Mice, Inbred Strains
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocyte Subsets
- Thyroid Gland
- Thyroiditis, Autoimmune