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Article

Castrated autoimmune glomerulonephritis mouse model shows attenuated glomerular sclerosis with altered parietal epithelial cell phenotype.

Experimental biology and medicine (Maywood, N.J.) - 1 Jun 2021

Otani Yuki, Ichii Osamu, Masum Md Abdul, Namba Takashi, Nakamura Teppei, Kon Yasuhiro

Abstract excerpt

Sex hormones help in maintaining proper immunity as well as renal homeostasis in mammals, and these multi-functional properties characterize the onset of sex-dependent diseases. To clarify the contribution of sex hormones to autoimmune disease-related renal pathogenesis, BXSB/MpJ-Yaa was investigated as a murine autoimmune glomerulonephritis model. BXSB/MpJ-Yaa and its wild-type, BXSB/MpJ-Yaa+ were castrated or...

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PMID: 33641441
DOI: 10.1177/1535370221996010
PMCID: PMC8371302

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