Article
Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2010
Kyttaris Vasileios C, Zhang Zheng, Kuchroo Vijay K, Oukka Mohamed, Tsokos George C
Abstract excerpt
IL-17-producing T cells infiltrate kidneys of patients with lupus nephritis, and IL-23-treated lymph node cells from lupus-prone mice may transfer disease to Rag1-deficient mice. In this study, we show that IL-23R-deficient lupus-prone C57BL/6-lpr/lpr mice display decreased numbers of CD3(+)CD4(-)CD8(-) cells and IL-17A-producing cells in the lymph nodes and produce less anti-DNA Abs. In addition, clinical and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.