Article
Lupus resistance is associated with marginal zone abnormalities in an NZM murine model.
Laboratory investigation; a journal of technical methods and pathology - 1 Jan 2007
Duan Biyan, Croker Byron P, Morel Laurence
Abstract excerpt
The NZM2410 and NZM TAN (TAN) are two of 27 inbred strains derived from an intercross between the NZW and NZB strains. NZM2410 mice develop a highly penetrant lupus nephritis mediated by three susceptibility loci, Sle1, Sle2 and Sle3. These three loci have been combined on a C57BL/6 background in a triple congenic strain that reconstitutes the NZM2410 autoimmune phenotype. Remarkably, inspite of the presence of...
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