Article
Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2006
Scalapino Kenneth J, Tang Qizhi, Bluestone Jeffrey A, Bonyhadi Mark L, Daikh David I
Abstract excerpt
An increasing number of studies indicate that a subset of CD4(+) T cells with regulatory capacity (regulatory T cells; T(regs)) can function to control organ-specific autoimmune disease. To determine whether abnormalities of thymic-derived T(regs) play a role in systemic lupus erythematosus, we evaluated T(reg) prevalence and function in (New Zealand Black x New Zealand White)F(1) (B/W) lupus-prone mice. To...
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