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Article

Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis.

Modern rheumatology - 1 Jan 2009

Igawa Takashi, Nakashima Hitoshi, Sadanaga Atsushi, Masutani Kohsuke, Miyake Katsuhisa, Shimizu Sakiko, Takeda Atsunobu, Hamano Shinjiro, Yoshida Hiroki

Abstract excerpt

MRL/lpr mice develop a systemic autoimmune disease that is reminiscent of systemic lupus erythematosus (SLE) and Sjögren's syndrome in humans. To investigate the role of IL-27 in the development of autoimmune disorders in MRL/lpr mice, we disrupted the EBV-induced gene 3 (EBI3), which is a subunit of IL-27. Consequently, the pathophysiology of glomerulonephritis and sialadenitis, which develops in MRL/lpr mice,...

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Share to Glomerulonephritis, Membranous
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18779924
DOI: 10.1007/s10165-008-0117-1

Genes

EBI3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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