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Article

H2A- and H2E-derived CD4+CD25+ regulatory T cells: a potential role in reciprocal inhibition by class II genes in autoimmune thyroiditis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2005

Morris Gerald P, Yan Yan, David Chella S, Kong Yi-Chi M

Abstract excerpt

We recently described a novel H2E class II-transgenic model (A(-)E(+)) of experimental autoimmune thyroiditis (EAT) that permits disease induction with heterologous thyroglobulin (Tg), but unlike conventional susceptible strains, precludes self-reactivity to autologous mouse Tg. In transgenic E(+)B10 (A(+)E(+)) mice, the presence of endogenous H2A genes is protective against H2E-mediated thyroiditis, inhibiting...

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Share to Adoptive Transfer
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to H-2 Antigens

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Share to Receptors, Interleukin-2

Share to T-Lymphocytes, Regulatory

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Source

Identifiers

PMID: 15728527
DOI: 10.4049/jimmunol.174.5.3111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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