Article
H2A- and H2E-derived CD4+CD25+ regulatory T cells: a potential role in reciprocal inhibition by class II genes in autoimmune thyroiditis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2005
Morris Gerald P, Yan Yan, David Chella S, Kong Yi-Chi M
Abstract excerpt
We recently described a novel H2E class II-transgenic model (A(-)E(+)) of experimental autoimmune thyroiditis (EAT) that permits disease induction with heterologous thyroglobulin (Tg), but unlike conventional susceptible strains, precludes self-reactivity to autologous mouse Tg. In transgenic E(+)B10 (A(+)E(+)) mice, the presence of endogenous H2A genes is protective against H2E-mediated thyroiditis, inhibiting...
Topics
- Adoptive Transfer
- Animals
- Antibodies, Monoclonal
- Disease Models, Animal
- Genes, MHC Class II
- Genetic Predisposition to Disease
- H-2 Antigens
- Histocompatibility Antigens Class II
- Humans
- Immunity, Innate
- Lymphocyte Depletion
- Mice
- Mice, Inbred C57BL