Article
A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015
Tahir Suhail, Fukushima Yuji, Sakamoto Keiko, Sato Kyosuke, Fujita Harumi, Inoue Joe, Uede Toshimitsu, Hamazaki Yoko, Hattori Masakazu, Minato Nagahiro
Abstract excerpt
Immune aging results in diminished adaptive immunity and increased risk for autoimmunity. We previously reported a unique PD-1(+) CD44(high)CD4(+) T cell population that increases with age in normal mice. In this study, we indicate that the age-dependent PD-1(+) CD44(high)CD4(+) T cells develop as unique T follicular (TF) cells in a B cell-dependent manner and consist of two subpopulations, as follows: CD153(+)...
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