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Article

A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2015

Chowdhary Vaidehi R, Dai Chao, Tilahun Ashenafi Y, Hanson Julie A, Smart Michele K, Grande Joseph P, Rajagopalan Govindarajan, Fu Shu-Man, David Chella S

Abstract excerpt

MHC, especially HLA-DR3 and HLA-DR2, is one of the most important genetic susceptibility regions for systemic lupus erythematosus. Human studies to understand the role of specific HLA alleles in disease pathogenesis have been hampered by the presence of strong linkage disequilibrium in this region. To overcome this, we produced transgenic mice expressing HLA-DR3 (DRβ1*0301) and devoid of endogenous class II (both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26475924
DOI: 10.4049/jimmunol.1501073
PMCID: PMC5292932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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