Article
Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.
Scientific reports - 30 Nov 2015
Lee Eun Young, Sakurai Kenichi, Zhang Xilin, Toda Chitoku, Tanaka Tomoaki, Jiang Meizi, Shirasawa Takuji, Tachibana Kaori, Yokote Koutaro, Vidal-Puig Antonio, Minokoshi Yasuhiko, Miki Takashi
Abstract excerpt
High-fat diet (HFD) triggers insulin resistance and diabetes mellitus, but their link remains unclear. Characterization of overt hyperglycemia in insulin receptor mutant (Insr(P1195L/+)) mice exposed to HFD (Insr(P1195L/+)/HFD mice) revealed increased glucose-6-phosphatase (G6pc) expression in liver and increased gluconeogenesis from glycerol. Lipolysis in white adipose tissues (WAT) and lipolysis-induced blood...
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