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Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets

16 Aug 2019

Abstract excerpt

Type 2 diabetes (T2D) is characterized by insufficient insulin secretion and elevated glucose levels, often in combination with high levels of circulating fatty acids. Long-term exposure to high levels of glucose or fatty acids impair insulin secretion in pancreatic islets, which could partly be due to epigenetic alterations. We studied the effects of high concentrations of glucose and palmitate combined for 48 h...

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Share to Epigenetics and DNA Methylation
Share to Metabolism, Diabetes, and Cancer
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PMID: 31420409
DOI: 10.2337/db18-0900

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