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Article

Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits.

Human molecular genetics - 15 Aug 2005

Glynn Dervila, Drew Cheney J, Reim Kerstin, Brose Nils, Morton A Jennifer

Abstract excerpt

Complexins are presynaptic proteins that bind to the SNARE complex where they modulate neurotransmitter release. A number of studies report changes in complexins in psychiatric (schizophrenia and depression) and neurodegenerative disorders (Huntington's disease, Wernicke's encephalopathy and Parkinson's disease). Here, we characterize the behavioural phenotype of Cplx1 knockout (Cplx1-/-) mice. Cplx1-/- mice...

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Identifiers

PMID: 16000319
DOI: 10.1093/hmg/ddi239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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