Article
Translational behavioral phenotypes in DMSXL mice for CNS manifestations of DM1.
Journal of neuromuscular diseases - 1 Sept 2026
Golini Elisabetta, Huguet-Lachon Aline, Benyamine Hélène, Forasté Gueriba Noëmy, Scavizzi Ferdinando, Raspa Marcello, Falcone Germana, Cardinali Beatrice, Mandillo Silvia, Gourdon Geneviève
Abstract excerpt
BACKGROUND: Myotonic dystrophy type 1 (DM1) is a multisystemic disorder frequently associated with central nervous system (CNS) involvement, especially in congenital and childhood-onset forms. However, behavioral alterations in preclinical models have so far been only partially characterized, underscoring the need for more comprehensive analyses to support the development of targeted therapeutic approaches....
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- Animals
- Myotonic Dystrophy
- Mice
- Phenotype
- Disease Models, Animal
- Behavior, Animal