Article

Loss of Piccolo function in rats induces Pontocerebellar Hypoplasia type 3-like phenotypes

2019-09-19

Abstract excerpt

Piccolo, a presynaptic active zone protein, is best known for its role in the regulated assembly and function of vertebrate synapses. Genetic studies suggest a further link to several psychiatric disorders as well as Pontocerebellar Hypoplasia type 3 (PCH3), although a causal relationship is lacking. We have characterized recently generated knockout ( Pclo gt/gt ) rats. Analysis revealed a dramatic reduction in...

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Literature Corpus work: dbfc5e9e-d269-55b1-b462-1e52e46f120b
DOI: 10.1101/774422

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