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Article

Improvement of cerebellar ataxic gait by injecting Cbln1 into the cerebellum of cbln1-null mice.

Scientific reports - 18 Apr 2018

Takeuchi Eri, Ito-Ishida Aya, Yuzaki Michisuke, Yanagihara Dai

Abstract excerpt

Patients and rodents with cerebellar damage display ataxic gaits characterized by impaired coordination of limb movements. Here, gait ataxia in mice with a null mutation of the gene for the cerebellin 1 precursor protein (cbln1-null mice) was investigated by kinematic analysis of hindlimb movements during locomotion. The Cbln1 protein is predominately produced and secreted from cerebellar granule cells. The...

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Identifiers

PMID: 29670152
DOI: 10.1038/s41598-018-24490-0
PMCID: PMC5906462

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