Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal.

Human molecular genetics - 1 Oct 2007

Drew Cheney J G, Kyd Rachel J, Morton A Jennifer

Abstract excerpt

Complexins are presynaptic proteins that modulate neurotransmitter release. Abnormal expression of complexin 1 (Cplx1) is seen in several neurodegenerative and psychiatric disorders in which disturbed social behaviour is commonplace. These include Parkinsons's disease, Alzheimer's disease, schizo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Cognition
Share to Cognition Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Grooming

Share to Maze Learning

Share to Memory Disorders

Share to Motor Activity

Share to Social Behavior

Source

Identifiers

PMID: 17652102
DOI: 10.1093/hmg/ddm181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17652102-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal.PMID 17652102Read ↗

Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits.Semantic proximity Read ↗

Early motor development is abnormal in complexin 1 knockout mice.Semantic proximity Read ↗

Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan.Semantic proximity Read ↗

HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems.Semantic proximity Read ↗

Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1.Semantic proximity Read ↗

Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice.Semantic proximity Read ↗

Cognitive, emotional and social phenotyping of mice in an observer-independent setting.Semantic proximity Read ↗

Phenotypic characterization of nonsocial behavioral impairment in neurexin 1α knockout rats.Semantic proximity Read ↗

Cognition in transmembrane domain neuregulin 1 mutant mice.Semantic proximity Read ↗

Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse.Semantic proximity Read ↗

Changes in object recognition and anxiety-like behaviour in mice expressing a Cx47 mutation that causes Pelizaeus-Merzbacher-like disease.Semantic proximity Read ↗

Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.