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Article

Systematic Phenotyping and Molecular Analysis of the Woozy Mouse: A Preclinical Model of Cerebellar Ataxia.

Molecular neurobiology - 6 Dec 2025

Bellia Fabio, Amodei Laura, Ruggieri Anna Giulia, Potenza Francesca, Viele Marianna, Bomba Manuela, Del Pizzo Francesco, Iezzi Manuela, Granzotto Alberto, Federici Luca, Sallese Michele

Abstract excerpt

Over the years, a diverse range of animal models has been established and employed in both basic and translational research, elucidating the intricate molecular mechanisms that drive cerebellar ataxias. However, many preclinical models remain insufficiently characterised, hindering our understanding of the diseases and the development of effective therapeutic approaches. The present study provides a comprehensive...

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Identifiers

PMID: 41350949
DOI: 10.1007/s12035-025-05577-y
PMCID: PMC12680694

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