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Article

Cerebellar Dysfunction as a Source of Dystonic Phenotypes in Mice

12 Jul 2022

Abstract excerpt

Abstract There is now a substantial amount of compelling evidence demonstrating that the cerebellum may be a central locus in dystonia pathogenesis. Studies using spontaneous genetic mutations in rats and mice, engineered genetic alleles in mice, shRNA knockdown in mice, and conditional genetic silencing of fast neurotransmission in mice have all uncovered a common set of behavioral and electrophysiological...

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PMID: 35821365
DOI: 10.1007/s12311-022-01441-0

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