Article
Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1.
PloS one - 1 Jan 2013
Steen Vidar M, Nepal Chirag, Ersland Kari M, Holdhus Rita, Nævdal Marianne, Ratvik Siri M, Skrede Silje, Håvik Bjarte
Abstract excerpt
Recent meta-analyses of schizophrenia genome-wide association studies (GWASs) have identified the CUB and SUSHI multiple domains 1 (CSMD1) gene as a statistically strong risk factor. CSMD1 is a complement control-related protein suggested to inhibit the classical complement pathway, being expressed in developing neurons. However, expression of CSMD1 is largely uncharacterized and relevance for behavioral...
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