Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan.

Pflugers Archiv : European journal of physiology - 1 Jan 2020

Xu Yang, Zhao Xiao-Ming, Liu Jia, Wang Yang-Yang, Xiong Liu-Lin, He Xiu-Ying, Wang Ting-Hua

Abstract excerpt

Complexin I (CPLX1), a presynaptic small molecule protein, forms SNARE complex in the central nervous system involved in the anchoring, pre-excitation, and fusion of axonal end vesicles. Abnormal expression of CPLX1 occurs in several neurodegenerative and psychiatric disorders that exhibit disrupted neurobehaviors. CPLX1 gene knockout induces severe ataxia and social behavioral deficits in mice, which has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Ataxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendrites

Share to Dystonia

Share to Exploratory Behavior

Share to Intestines

Share to Movement

Share to Stomach

Source

Identifiers

PMID: 31875236
DOI: 10.1007/s00424-019-02337-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan.PMID 31875236Read ↗

Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits.Semantic proximity Read ↗

Early motor development is abnormal in complexin 1 knockout mice.Semantic proximity Read ↗

Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal.Semantic proximity Read ↗

Improvement of cerebellar ataxic gait by injecting Cbln1 into the cerebellum of cbln1-null mice.Semantic proximity Read ↗

Loss of the Familial Dysautonomia gene <i>Elp1</i> in cerebellar granule cell progenitors leads to ataxia in miceSemantic proximity Read ↗

Systematic Phenotyping and Molecular Analysis of the Woozy Mouse: A Preclinical Model of Cerebellar Ataxia.Semantic proximity Read ↗

Cerebellar Dysfunction as a Source of Dystonic Phenotypes in MiceSemantic proximity Read ↗

Mouse Models of <i>GNAO1</i> -Associated Movement Disorder: Allele- and sex-specific differences in phenotypesSemantic proximity Read ↗

Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction.Semantic proximity Read ↗

Loss of Elp1 in cerebellar granule cell progenitors models ataxia phenotype of Familial Dysautonomia.Semantic proximity Read ↗

Zebrafish knockout models of atxn1a, atxn1b, and atxn1l reveal distinct and shared phenotypic and transcriptomic alterations.Semantic proximity Read ↗

Generation and characterization of a knock-in mouse model for Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly (SPATCCM)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.